MRI in Animal Models of Psychiatric Disorders

  • Dana S. Poole
  • Melly S. Oitzl
  • Louise van der Weerd
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 771)

Abstract

Here we describe MRI and 1H MRS protocols for the investigation of animal models (mainly mice and rats) of psychiatric disorders. The introduction provides general findings from brain imaging studies in patients with psychiatric diseases and refers to general rules regarding the use of animal models in research. The methods section includes a selection of basic 9.4 T MRI and MRS protocols applicable for the investigation of animal models of psychiatric disorders (T1W, T2W, FLAIR, 1H MRS). The notes section discusses in detail a series of factors that can influence the outcome of the experiment: from animal handling, stress-triggering aspects, and experimental design-related factors to technical aspects that affect T 1 and T 2 measurements.

Key words

Animal MRI 1H NMR spectroscopy methods imaging methods magnetic resonance imaging magnetic resonance spectroscopy methodological considerations mood disorders MRI protocols stress 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Dana S. Poole
    • 1
  • Melly S. Oitzl
    • 2
  • Louise van der Weerd
    • 3
  1. 1.Department of RadiologyLeiden University Medical CenterLeidenThe Netherlands
  2. 2.Division of Medical PharmacologyUniversity of LeidenLeidenThe Netherlands
  3. 3.Department of Radiology, Anatomy and EmbryologyLeiden University Medical CenterLeidenThe Netherlands

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