Proprotein Convertases pp 343-363

Part of the Methods in Molecular Biology book series (MIMB, volume 768) | Cite as

Neurophenotyping Genetically Modified Mice for Social Behavior

  • Ramona M. Rodriguiz
  • Jennifer S. Colvin
  • William C. Wetsel


Sociability in mice is a multidimensional adaptive and functional response. Due to its complexity, it is important that researchers use well-defined behavioral assays that are easily replicated with clearly defined ethograms. In the Mouse Behavioral and Neuroendocrine Analysis Core Facility at Duke University, we have developed a broad series of tests that examine different components of neonatal and adult social behaviors that include sociability, sexual behavior, aggressive and territorial responses, and maternal behaviors. While the purpose of this chapter is not to provide an exhaustive description of all mouse social tests available, we provide investigators with a description of basic procedures and considerations necessary to develop a successful social behavior testing program within their laboratories.

Key words

Social behavior sociability aggression sexual behavior resident-intruder social dyadic maternal behavior mother–pup interactions ultrasonic vocalizations 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Ramona M. Rodriguiz
    • 1
  • Jennifer S. Colvin
    • 2
  • William C. Wetsel
    • 3
  1. 1.Department of Psychiatry and Behavioral Sciences and Mouse Behavioral and Neuroendocrine Analysis Core FacilityDuke University Medical CenterDurhamUSA
  2. 2.Department of Psychiatry and Behavioral SciencesDuke University Medical CenterDurhamUSA
  3. 3.Department of Psychiatry and Behavioral Sciences, Cell Biology, and NeurobiologyMouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical CenterDurhamUSA

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