In Vitro Neurotoxicology pp 1-9 | Cite as
In Vitro Neurotoxicology: An Introduction
Protocol
First Online:
Abstract
This introductory Chapter provides a brief overview of the field of neurotoxicology and of the role played by in vitro approaches in investigations on mechanisms of neurotoxicity and of developmental neurotoxicity, and in providing suitable models for neurotoxicity screening.
Key words
In vitro models In vitro endpoints Mammalian cell culturesReferences
- 1.ECETOC. Evaluation of the Neurotoxic Potential of Chemicals. Brussels, European Center for Ecotoxicology and Toxicology of Chemicals, 1992.Google Scholar
- 2.Spencer PS, Schaumburg HH, Ludolph AC (Eds) (2000) Experimental and Clinical Neurotoxicology. Oxford University Press, Oxford, pp. 1310.Google Scholar
- 3.Grandjean P, Landrigan PJ (2006) Developmental neurotoxicity of industrial chemicals. Lancet 368: 2167–2178.PubMedCrossRefGoogle Scholar
- 4.Hatcher JM, Pennell KD, Miller GW (2008) Parkinson’s disease and pesticides: a toxicological perspective. Trends Pharmacol. Sci. 29: 323–329.CrossRefGoogle Scholar
- 5.OECD (Organization for Economic Co-operation and Development) (1997) Test Guideline 424. OECD Guideline for Testing of Chemicals. Neurotoxicity study in rodents. Paris, OECD.Google Scholar
- 6.USEPA (United States Environmental Protection Agency) (1998) Health Effects Test Guidelines. OPPTS 870.6200. Neurotoxicity screening battery. Washington DC, USEPA.Google Scholar
- 7.Costa LG (1998) Neurotoxicity testing: a discussion of in vitro alternatives. Environ. Health Perspect. 106 (Suppl. 2): 505–510.PubMedGoogle Scholar
- 8.USEPA (United States Environmental Protection Agency) (1998) Health Effects Test Guidelines. OPPTS 870.6300. Developmental neurotoxicity study. Washington DC, USEPA, 1998.Google Scholar
- 9.OECD (Organization for Economic Co-operation and Development). (2007) Test Guideline 426. OECD Guideline for Testing of Chemicals. Developmental neurotoxicity study. Paris, OECD.Google Scholar
- 10.Bal-Price AK, Hogberg HT, Buzanska L, Coecke S (2010) Relevance of in vitro neurotoxicity testing for regulatory requirements: challenges to be considered. Neurotoxicol. Teratol. 32; 36–41.PubMedCrossRefGoogle Scholar
- 11.Harry GJ, Billingsley M, Bruinink A, Campbell IL, Classen W, Dorman DC, Galli C, Ray D, Smith RA, Tilson HA (1998) In vitro techniques for the assessment of neurotoxicity. Environ. Health Perspect. 106 (Suppl. 1): 131–158.PubMedGoogle Scholar
- 12.Costa LG, Giordano G, Guizzetti M (2011) Predictive models for neurotoxicity assessment. In: Xu JJ, Urban L (eds) Predictive Toxicology in Drug Safety, Cambridge University Press, pp. 135–152.Google Scholar
- 13.Giordano G, White CC, Mohar I, Kavanagh TJ, Costa LG (2007) Glutathione levels modulate domoic acid-induced apoptosis in mouse cerebellar granule cells. Toxicol. Sci. 100: 433–444.PubMedCrossRefGoogle Scholar
- 14.Guizzetti M, Thompson BD, Kim Y, VanDeMark K, Costa LG (2004) Role of phospholipase D signaling in ethanol induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells. J. Neurochem. 90: 646–653.PubMedCrossRefGoogle Scholar
- 15.Kodavanti PR, Ward TR (2005) Differential effects of commercial polybrominated diphenyl ether and polychlorinated biphenyl mixtures on intracellular signaling in rat brain in vitro. Toxicol. Sci. 85: 952–962.PubMedCrossRefGoogle Scholar
- 16.Giordano G, Kavanagh TJ, Costa LG (2009a) Mouse cerebellar astrocytes protect cerebellar granule neurons against toxicity of the polybrominated diphenyl ether (PBDE) mixture DE-71. Neurotoxicology. 30: 326–329.PubMedCrossRefGoogle Scholar
- 17.Giordano G, Pizzurro D, VanDeMark KL, Guizzetti M, Costa LG (2009b) Manganese inhibits the ability of astrocytes to promote neuronal differentiation. Toxicol. Appl. Pharmacol. 240: 226–235.PubMedCrossRefGoogle Scholar
- 18.Janigro D, Costa LG (1987) Effects of trimethyltin on granule cells excitability in the in vitro rat dentate gyrus. Neurotoxicol. Teratol. 9: 33–38.PubMedCrossRefGoogle Scholar
- 19.Goldoni M, Vettori MV, Alinovi R, Caglieri A, Ceccatelli S, Mutti A (2003) Models of neurotoxicity: extrapolation of threshold doses in vitro. Risk Anal. 23: 505–514.PubMedCrossRefGoogle Scholar
- 20.Coecke S, Eskes C, Gartlon J, Kinsner A, Price A, van Vliet E, Prieto P, Boveri M, Bremer S, Adler S, Pellizzer C, Wendel A, Hartung T (2006) The value of alternative testing for neurotoxicity in the context of regulatory needs. Environ. Toxicol. Pharmacol. 21: 153–167.PubMedCrossRefGoogle Scholar
- 21.Tiffany-Castiglioni E, Ehrich M, Dees L, Costa LG, Kodavanti PRS, Lasley SM, Oortgiesen M, Durham HD (1999) Bridging the gap betwen in vitro and in vivo models. Toxicol. Sci. 51: 178–183.PubMedCrossRefGoogle Scholar
- 22.Gartlon J, Kinsner A, Bal-Price A, Coecke S, Clothier RH (2006) Evaluation of a proposed in vitro test strategy using neuronal and non-neuronal cell systems for detecting neurotoxicity. Toxicol. In Vitro 20: 1569–1581.PubMedCrossRefGoogle Scholar
- 23.Breier JM, Radio NM, Mundy WR, Shafer TJ (2008) Development of a high-throughput screening assay for chemical effects on proliferation and viability of immortalized human neural progenitor cells. Toxicol. Sci. 105: 119–133.PubMedCrossRefGoogle Scholar
- 24.Costa LG, Fattori V, Giordano G, Vitalone A (2007) An in vitro approach to assess the toxicity of certain food contaminants: methylmercury and polychlorinated biphenyls. Toxicology 237: 65–76.PubMedCrossRefGoogle Scholar
- 25.Radio NM, Mundy WR (2008) Developmental neurotoxicity testing in vitro: models for assessing chemical effects on neurite outgrowth. Neurotoxicology. 29: 361–376.PubMedCrossRefGoogle Scholar
- 26.Radio NM, Breier JM, Shafer TJ, Mundy WR (2008) Assessment of chemical effects on neurite outgrowth in PC12 cells using high content screening. Toxicol. Sci. 105: 106–118.PubMedCrossRefGoogle Scholar
- 27.Van Vliet E, Morath S, Eskes C, Linge J, Rappsilber J, Honegger P, Hartung T, Coecke S (2008) A novel metabolomics approach for neurotoxicity testing, proof of principle for methylmercury chloride and caffeine. Neurotoxicology. 29: 1–12.PubMedCrossRefGoogle Scholar
- 28.Van Vliet E, Stoppini L, Balestrino M, Eskes C, Griesinger C, Sobanski T, Whelan M, Hartung T, Coecke S (2007) Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects. Neurotoxicology. 28: 1136–1146.PubMedCrossRefGoogle Scholar
- 29.Lotti M, Moretto A (2005) Organophosphate-induced delayed polyneuropathy. Toxicol. Rev. 24: 37–49.PubMedCrossRefGoogle Scholar
- 30.Ehrich M, Correll L, Veronesi B (1997) Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity. Fund. Appl. Toxicol. 38: 55–63.CrossRefGoogle Scholar
Copyright information
© Springer Science+Business Media, LLC 2011