MR Spectroscopy and Spectroscopic Imaging of the Brain

Part of the Methods in Molecular Biology book series (MIMB, volume 711)


Magnetic resonance spectroscopy (MRS) and the related technique of magnetic resonance spectroscopic imaging (MRSI) are widely used in both clinical and preclinical research for the non-invasive evaluation of brain metabolism. They are also used in medical practice, although their ultimate clinical value continues to be a source of discussion. This chapter reviews the general information content of brain spectra and commonly used protocols for both MRS and MRSI and also touches on data analysis methods and quantitation. The main focus is on proton MRS for application in humans, but many of the methods are also applicable to other nuclei and studies of animal models as well.

Key words

Brain magnetic resonance spectroscopy spectroscopic imaging spatial localization metabolites 



Supported in part by National Institutes of Health grant P41 RR015241.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Russell H. Morgan Department of Radiology and Radiological ScienceJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.The Kennedy Krieger InstituteBaltimoreUSA

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