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Protein Misfolding and Cellular Stress in Disease and Aging

Volume 648 of the series Methods in Molecular Biology pp 93-106

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Mitophagy and Mitoptosis in Disease Processes

  • Dalibor MijaljicaAffiliated withDepartment of Biochemistry and Molecular Biology, Monash University
  • , Mark PrescottAffiliated withDepartment of Biochemistry and Molecular Biology, Monash University
  • , Rodney J. DevenishAffiliated withDepartment of Biochemistry and Molecular Biology and the ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University Email author 

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Abstract

Mitochondria play a very important role in cellular function, not only through key metabolic reactions and energy generation, but also by being a major site for production of reactive oxygen species and a key player in cell death. Therefore, mitochondrial dysfunction or damage may have severe consequences. Mitophagy (autophagic degradation of mitochondria) and mitoptosis (programmed destruction of mitochondria) are the processes by which cells can deal with impaired mitochondria. The efficiency of these processes may be a contributing factor to the pathogenesis of various diseases.

Key words

Damage Degradation Disease Mitochondria Mitophagy Mitoptosis