Statistical Contributions to Proteomic Research

  • Jeffrey S. Morris
  • Keith A. Baggerly
  • Howard B. Gutstein
  • Kevin R. Coombes
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 641)

Abstract

Proteomic profiling has the potential to impact the diagnosis, prognosis, and treatment of various diseases. A number of different proteomic technologies are available that allow us to look at many proteins at once, and all of them yield complex data that raise significant quantitative challenges. Inadequate attention to these quantitative issues can prevent these studies from achieving their desired goals, and can even lead to invalid results. In this chapter, we describe various ways the involvement of statisticians or other quantitative scientists in the study team can contribute to the success of proteomic research, and we outline some of the key statistical principles that should guide the experimental design and analysis of such studies.

Key words

Blocking Data preprocessing Experimental design False discovery rate Image processing Mass spectrometry Peak detection Randomization Spot detection 2D gel electrophoresis Validation 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jeffrey S. Morris
    • 1
  • Keith A. Baggerly
    • 2
  • Howard B. Gutstein
    • 3
  • Kevin R. Coombes
    • 2
  1. 1.Department of BiostatisticsThe University of Texas M. D. Anderson Cancer CenterHoustonUSA
  2. 2.Department of Bioinformatics and Computational BiologyThe University of Texas M. D. Anderson Cancer CenterHoustonUSA
  3. 3.Department of Anesthesiology and Perioperative MedicineThe University of Texas M. D. Anderson Cancer CenterHoustonUSA

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