Volume 640 of the series Methods in Molecular Biology pp 525-534


Human Hepatocyte Transplantation

  • Anil DhawanAffiliated withKing’s Cell Isolation Unit, King’s College Hospital Email author 
  • , Stephen C. StromAffiliated withDepartment of Pathology, University of Pittsburgh
  • , Etienne SokalAffiliated withPediatric Department, Université Catholique de Louvain
  • , Ira J. FoxAffiliated withDepartment of Surgery, University of Nebraska Medical Center

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Over the last decade the interest in hepatocyte transplantation has been growing continuously and this treatment may represent an alternative clinical approach for patients with acute liver failure and life-threatening liver-based metabolic disorders. The technology also serves as the proof of concept and reference for future development in stem cell technology. This chapter reviews the field of hepatocyte transplantation from bench to bedside.

Key words

Hepatocyte transplantation collagenase cryopreservation liver tissue source GMP laboratory metabolic liver disease acute liver failure stem cells immunosuppression