Non-invasive Blood Pressure Measurement in Mice

  • Minjie Feng
  • Keith DiPetrillo
Protocol
Part of the Methods in Molecular Biology™ book series (MIMB, volume 573)

Abstract

Hypertension is a leading cause of heart attack, stroke, and kidney failure and represents a serious medical issue worldwide. The genetic basis of hypertension is well-established, but few causal genes have been identified thus far. Non-invasive blood pressure measurements are a critical component of high-throughput genetic studies to identify genes controlling blood pressure. Whereas this technique is fairly routine for blood pressure measurements in rats, non-invasive blood pressure measurement in mice has proven to be more challenging. This chapter describes an experimental protocol measuring blood pressure in mice using a CODA non-invasive blood pressure monitoring system. This method enables accurate blood pressure phenotyping in mice for linkage or mutagenesis studies, as well as for other experiments requiring high-throughput blood pressure measurement.

Key words

Tail-cuff blood pressure mice high-throughput 

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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Minjie Feng
    • 1
  • Keith DiPetrillo
    • 1
  1. 1.Novartis Institutes for BioMedical Research and Novartis Pharmaceutical CorporationEast HanoverUSA

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