Modeling Spatial and Temporal Dynamics of Chemotactic Networks
When stimulated by chemoattractants, eukaryotic cells respond through a combination of temporal and spatial dynamics. These responses come about because of the interaction of a large number of signaling components. The complexity of these systems makes it hard to understand without a means of systematically generating and testing hypotheses. Computer simulations have proved to be useful in testing conceptual models. Here we outline the steps required to develop these models.
Key words:Mathematical model Chemotaxis Reaction–diffusion Systems biology Virtual cell
- 12.Ma, L., Janetopoulos, C., Yang, L., Devreotes, P. N., and Iglesias, P. A. (2004) Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in Dictyostelium cells. Biophys. J. 87, 3764–3774.PubMedCrossRefGoogle Scholar
- 14.Bathe, K.-J. (1996) Finite Element Procedures. Prentice Hall, Englewood Cliffs, NJ.Google Scholar