Chemotaxis pp 489-505 | Cite as

Modeling Spatial and Temporal Dynamics of Chemotactic Networks

  • Liu Yang
  • Pablo A. Iglesias
Part of the Methods in Molecular Biology™ book series (MIMB, volume 571)


When stimulated by chemoattractants, eukaryotic cells respond through a combination of temporal and spatial dynamics. These responses come about because of the interaction of a large number of signaling components. The complexity of these systems makes it hard to understand without a means of systematically generating and testing hypotheses. Computer simulations have proved to be useful in testing conceptual models. Here we outline the steps required to develop these models.

Key words:

Mathematical model Chemotaxis Reaction–diffusion Systems biology Virtual cell 


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Copyright information

© Humana Press 2009

Authors and Affiliations

  • Liu Yang
    • 1
  • Pablo A. Iglesias
    • 1
  1. 1.Department of Electrical and Computer EngineeringThe Johns Hopkins UniversityBaltimoreUSA

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