Bacterial Genome Sequencing

  • Hervé Tettelin
  • Tamara Feldblyum
Part of the Methods in Molecular Biology™ book series (MIMB, volume 551)


For over 30 yr, the Sanger method has been the standard for DNA sequencing. Instruments have been developed and improved over time to increase throughput, but they always relied on the same technology. Today, we are facing a revolution in DNA sequencing with many drastically different platforms that have become or will soon become available on the market. We review a number of sequencing technologies and provide examples of applications. We also discuss the impact genomics and new DNA sequencing approaches have had on various fields of biological research.

Key words

Bacteria diversity genome pathogen sequencing technology 


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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Hervé Tettelin
    • 1
  • Tamara Feldblyum
    • 1
  1. 1. Institute for Genome Sciences, Department of Microbiology and ImmunologyUniversity of Maryland School of MedicineBaltimoreUSA

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