Inferring Functional Relationships from Conservation of Gene Order
The idea behind the gene neighbor method is that conservation of gene order in evolutionarily distant prokaryotes indicates functional association. The procedure presented here starts with the organization of all the genomes into pairs of adjacent genes. Then, pairs of genes in a genome of interest are mapped to their corresponding orthologs in other, informative, genomes. The final step is to determine whether the orthologs of each original pair of genes are also adjacent in the informative genome.
Key words:Conservation of gene order operon genomic context functional inference gene neighbor method
Research support from Wilfrid Laurier University, and as SHARCNET Chair in Biocomputing are acknowledged.