Rat Genomics pp 243-266 | Cite as

Generation of Congenic and Consomic Rat Strains

  • Dominique Lagrange
  • Gilbert J Fournié
Part of the Methods in Molecular Biology book series (MIMB, volume 597)


Congenic and consomic rat strains are inbred strains containing in their genome a given genomic region (congenic) or a whole chromosome (consomic) from another strain. They are nowadays invaluable tools for the identification of genes and mechanisms of multifactorial diseases, one of the main goals in biomedicine. They are produced by repeated backcrosses from a donor inbred strain to a recipient inbred strain, and thereafter maintained by conventional brother-x-sister mating. Although their production is lengthy and costly, it only requires a zootechny unit for breeding and tools for genotyping.

Key words

Congenic rat Consomic rat Genetic dissection Complex traits Quantitative trait locus Positional cloning Polygenic disease 



The authors want to thanks the following participants in the works done on rat congenics in our laboratory: Pr Philippe Druet, who has initiated the work on rat genomics; Dr Abdelhadi Saoudi, who has collaborated in most of the studies; Dr Dominique Gauguier, who has helped us to create the first congenic strains; all the students who have participated in the construction of congenic strains and sub-strains, particularly Drs Magali Mas, Jean-François Subra, Pierre Cavaillès, Céline Colacios and Olivier Papapietro and all the persons who are or have been in care of the rats in our Zootechnic unit, particularly Mrs Maryline Calise, Sylvie Appolinaire, Audrey Boyer, Marie-Andrée Daussion, Corinne Senty, Carine Segui, Magali Toulouse, Aline Tridon, Mr. Patrick Aregui, Thierry Ruiz.

The development of the congenic strains in our laboratory has been supported by grants from Institut National de la Santé et de la Recherche Médicale (INSERM), Genopole® Toulouse Midi-Pyrénées (GenoToul), Agence Nationale de Recherche (ANR), Fondation pour la Recherche Médicale (FRM), Association de Recherche sur la Polyarthrite Rhumatoïde (ARP) and Fondation Arthritis Courtin, Association de Recherche sur la Sclérose en Plaques (ARSEP), Association Française contre les Myopathies (AFM), Etablissement Français des Greffes (EFG), Ligue Contre le Cancer (LCC), Université Paul Sabatier (UPS), Région Midi-Pyrénées, Ministère de l’Aménagement du Territoire et de l’Environnement and Ministère Délégué à la Recherche et aux Nouvelles Technologies.


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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.INSERM, U563ToulouseFrance
  2. 2.Université Toulouse III Paul Sabatier, Institut Claude de Préval (IFR30)ToulouseFrance

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