Gene Selection with the δ-Sequence Method

Part of the Methods in Molecular Biology book series (MIMB, volume 972)


In this chapter, we discuss a method of selecting differentially expressed genes based on a newly discovered structure termed as the δ-sequence. Together with the nonparametric empirical Bayes methodology, it leads to dramatic gains in terms of the mean numbers of true and false discoveries, and in the stability of the results of testing. Furthermore, its outcomes are entirely free from the log-additive array-specific technical noise. The new paradigm offers considerable scope for future developments in this area of methodological research.

Key words

Microarray data Correlation Differential expression Gene pairs 



This research is supported by NIH Grant GM079259 (X. Qiu) and by Theodosius Dobzhansky Center for Genome Bioinformatics (L. Klebanov).


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Biostatistics and Computational BiologyUniversity of RochesterRochesterUSA
  2. 2.Department of Probability Statistics Charles University PraguePragueCzech Republic

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