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Middle Cerebral Artery Occlusion Suture Model for Mice

  • Feng Zhang
  • Steven H. Graham
  • Jun  Chen
Protocol
Part of the Springer Protocols Handbooks book series (SPH)

This chapter introduces the procedure, assessment, application, limitations, and technical considerations of the popular focal brain ischemia model in mice, the middle cerebral artery occlusion (MCAO) suture model. Preparation of the suture, surgical procedures, examination of neurological function, and infarct volume assessment are described in detail.

Keywords

Mouse Stroke Brain ischemia MCAO Suture 

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References

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Copyright information

© Humana Press, a part of Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Feng Zhang
    • 1
  • Steven H. Graham
    • 1
  • Jun  Chen
    • 1
  1. 1.Department of NeurologyUniversity of Pittsburgh School of MedicinePittsburghUSA

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