- 2k Downloads
This chapter outlines the important points that must be considered in developing an animal protocol using a model of acute neurological injury. It highlights the issues that should be considered in designing such a study as well as the issues that must be addressed when writing a protocol for submission to the Institutional Animal Care and Use Committee (IACUC). The key issues for regulatory compliance are addressed.
KeywordsAnimal protocol IACUC Regulatory compliance
Unable to display preview. Download preview PDF.
- 1.CFR (Code of Federal Regulations). 1985. Title 9: Animals and Animal Products, Chapter 1, Subchapter A: Animal Welfare. Washington, DC: Office of Federal RegisterGoogle Scholar
- 2.PHS (Public Health Service). 1996. Public Health Service Policy on Humane Care and Use of Laboratory Animals. Washington, DC: U.S. Department of Health and Human Services, 28 pp. [PL 99–158, Health Research Extension Act, 1985]Google Scholar
- 3.IRAC (Interagency Research Animal Committee). 1985 US Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training. Washington, DC: Office of Science and Technology PolicyGoogle Scholar
- 4.NRC (National Research Council). 2003. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research. Washington, DC: National Academies PressGoogle Scholar
- 5.NRC (National Research Council). 1996. The Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academies PressGoogle Scholar
- 6.NIH (National Institutes of Health). 2002. Methods and Welfare Considerations in Behavioral Research with Animals: Report of a National Institutes of Health Workshop. Morrison, A.R., Evans, H.L., Ator, N.A., Nakamura, R.K. (eds). NIH Publication No. 02–5083. Washington, DC: US Government Printing OfficeGoogle Scholar
- 7.Stokes, W.S. Reducing unrelieved pain and distress in laboratory animals using humane endpoints. ILAR J 2000; 41(2):59–61Google Scholar
- 8.ARENA-OLAW (Applied Research Ethics National Association – Office of Laboratory Animal Welfare). 2002. Institutional Animal Care and Use Committee Guidebook (2nd ed). Washington, DC: US Government Printing PressGoogle Scholar
- 10.AVMA (American Veterinary Medical Association). 2000 Report of the AVMA panel on euthanasia. J Am Vet Med Assoc. 2001; 218(5):669–696Google Scholar
- 11.NRC (National Research Council). 1997. Occupational Health and Safety in the Care and Use of Research Animals. Washington, DC: National Academies PressGoogle Scholar