Immunoinformatics pp 43-60

Part of the Methods in Molecular Biology™ book series (MIMB, volume 409) | Cite as

The IMGT/HLA Database

  • James Robinson
  • Steven G.E. Marsh

Summary

The human leukocyte antigen (HLA) complex is located within the 6p21.3 region on the short arm of human chromosome 6 and contains more than 220 genes of diverse function. Many of the genes encode proteins of the immune system and include many highly polymorphic HLA genes. The naming of new HLA genes and allele sequences and their quality control is the responsibility of the WHO Nomenclature Committee for Factors of the HLA System. The IMGT/HLA Database acts as the repository for these sequences and is recognized as the primary source of up-to-date and accurate HLA sequences. The IMGT/HLA website provides a number of tools for accessing the database: these include allele reports, sequence alignments, and sequence similarity searches. The website is updated every 3 months with all the new and confirmatory sequences submitted to the WHO Nomenclature Committee. Submission of HLA sequences to the committee is possible through the tools provided by the IMGT/HLA Database.

Key Words

HLA MHC nomenclature sequences alleles database 

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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • James Robinson
    • 1
  • Steven G.E. Marsh
    • 2
  1. 1.Anthony Nolan Research Institute, Royal Free HospitalHampstead, LondonUK
  2. 2.Department of HaematologyAnthony Nolan Research Institute, Royal Free HospitalHampstead, LondonUK

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