TAPPred Prediction of TAP-Binding Peptides in Antigens

  • Manoj Bhasin
  • Sneh Lata
  • G.P.S. Raghava
Part of the Methods in Molecular Biology™ book series (MIMB, volume 409)


The transporter associated with antigen processing (TAP) plays a crucial role in the transport of the peptide fragments of the proteolysed antigenic or self-altered proteins to the endoplasmic reticulum where the association between these peptides and the major histocompatibility complex (MHC) class I molecules takes place. Therefore, prediction of TAP-binding peptides is highly helpful in identifying the MHC class I-restricted T-cell epitopes and hence in the subunit vaccine designing. In this chapter, we describe a support vector machine (SVM)-based method TAPPred that allows users to predict TAP-binding affinity of peptides over web. The server allows user to predict TAP binders using a simple SVM model or cascade SVM model. The server also allows user to customize the display/output. It is freely available for academicians and noncommercial organization at the address

Key Words

TAP MHC class I T-cell epitopes subunit vaccine SVM cascade SVM 



We acknowledge the financial support from the Council of Scientific and Industrial Research (CSIR) and Department of Biotechnology (DBT), Government of India.


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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Manoj Bhasin
    • 1
  • Sneh Lata
    • 1
  • G.P.S. Raghava
    • 1
    • 2
  1. 1.Institute of Microbial TechnologyChandigarhIndia
  2. 2.UAMS, BRCIILittle Rock

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