Drosophila melanogaster and the Development of Biology in the 20th Century

  • Alfonso Martinez Arias
Part of the Methods in Molecular Biology book series (MIMB, volume 420)


The fruit fly Drosophila has played a central role in the development of biology during the 20th century. First chosen as a convenient organism to test evolutionary theories soon became the central element in an elaborate, fruitful, and insightful research program dealing with the nature and function of the gene. Through the activities of TH Morgan and his students, Drosophila did more than any other organism to lay down the foundations of genetics as a discipline and a tool for biology. In the last third of the century, a judicious blend of classical genetics and molecular biology focused on some mutants affecting the pattern of the Drosophila larva and the adult, and unlocked the molecular mechanisms of development. Surprisingly, many of the genes identified in this exercise turned to be conserved across organisms. This observation provided a vista of universality at a fundamental level of biological activity. At the dawn of the 21st century, Drosophila continues to be center stage in the development of biology and to open new ways of seeing cells and to understand the construction and the functioning of organisms.

Key Words

Development Drosophila fruit fly genes genetics history 


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Copyright information

© Humana Press Inc., Totowa, NJ 2008

Authors and Affiliations

  • Alfonso Martinez Arias
    • 1
  1. 1.Department of GeneticsUniversity of CambridgeCambridgeUK

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