Roadmap Methods for Protein Folding

  • Mark Moll
  • David Schwarz
  • Lydia E. Kavraki
Part of the Methods in Molecular Biology™ book series (MIMB, volume 413)


Protein folding refers to the process whereby a protein assumes its intricate three-dimensional shape. This chapter reviews a class of methods for studying the folding process called roadmap methods. The goal of these methods is not to predict the folded structure of a protein, but rather to analyze the folding kinetics. It is assumed that the folded state is known. Roadmap methods maintain a graph representation of sampled conformations. By analyzing this graph one can predict structure formation order, the probability of folding, and get a coarse view of the energy landscape.


protein folding folding kinetics roadmap methods conformation sampling techniques energy landscape 


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Copyright information

© Humana Press Inc 2008

Authors and Affiliations

  • Mark Moll
  • David Schwarz
  • Lydia E. Kavraki

There are no affiliations available

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