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The SUMO System: An Overview

  • Helle D. Ulrich
Part of the METHODS IN MOLECULAR BIOLOGY™ book series (MIMB, volume 497)

Abstract

Post-translational modification by SUMO is now recognized as an important regulatory method employed by the cell to reversibly modulate the activity, stability, or localization of intracellular proteins. A dedicated enzymatic machinery is involved in the processing, attachment, and removal of the modifier with high selectivity. SUMO modification generally alters the properties of the modified target by influencing—either positively or negatively—its interactions with other cellular factors. As a consequence, the SUMO system contributes to the regulation of numerous biological pathways, ranging from nucleocytoplasmic transport to the repression of transcriptional activity and the maintenance of genome stability by its influence on DNA recombination and repair. This chapter gives a brief overview over the enzymes of the SUMO system, its regulation, and its functions.

Keywords

SUMO SUMO-activating enzyme (E1) SUMO-conjugating enzyme (E2) SUMO ligase (E3) SUMO-specific isopeptidase (SENP) SUMO interaction motif (SIM) SUMO-binding motif (SBM) 

Notes

Acknowledgments

I apologize to those researchers whose work could not be cited directly in this review due to space constraints. Work in this laboratory is supported by Cancer Research UK.

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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Helle D. Ulrich
    • 1
  1. 1.Cancer Research UK London Research InstituteClare Hall LaboratoriesUK

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