Constructing Realistic Neural Simulations with GENESIS

  • James M. Bower
  • David Beeman
Part of the Methods in Molecular Biology™ book series (MIMB, volume 401)


The GEneral NEural SImulation System (GENESIS) is an open source simulation platform for realistic modeling of systems ranging from subcellular components and biochemical reactions to detailed models of single neurons, simulations of large networks of realistic neurons, and systems-level models. The graphical interface XODUS permits the construction of a wide variety of interfaces for the control and visualization of simulations. The object-oriented scripting language allows one to easily construct and modify simulations built from the GENESIS libraries of simulation components. Here, we present procedures for installing GENESIS and its supplementary tutorials, running GENESIS simulations, and creating new neural simulations.


Computational neuroscience realistic neural modeling simulations GENESIS tutorials 



This work was supported by NIH grant R01 NS049288-01.


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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • James M. Bower
    • 1
  • David Beeman
    • 2
  1. 1.Research Imaging Center, University of Texas Health Science Center and Cajal Neuroscience CenterUniversity of TexasSan Antonio
  2. 2.Department of Electrical and Computer EngineeringUniversity of ColoradoBoulder

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