Micro and Nano Technologies in Bioanalysis pp 559-569

Part of the Methods in Molecular Biology™ book series (MIMB, volume 544)

Magnetic Nanoparticles for Local Drug Delivery Using Magnetic Implants

  • Rodrigo Fernández-Pacheco
  • J. Gabriel Valdivia
  • M. Ricardo Ibarra
Protocol

Summary

This chapter is a brief description of the state of the art of the field of targeted drug delivery using magnetic implants. It describes the advantages and drawbacks of the use of internal magnets to concentrate magnetic nanoparticles near tumor locations, and the different approaches to this task performed in vitro and in vivo reviewed in literature are presented.

Key words

Magnetic Implants Magnetic nanoparticles Drug delivery 

References

  1. 1.
    Cha, Y., Chen, L., Askew, T., Veal, B., Hull, J. (2007). Manipulation of magnetic carriers for drug delivery using pulsed-current high Tc superconductors. J. Magn. Magn. Mater. 311, 312–317.CrossRefGoogle Scholar
  2. 2.
    Alexiou, C., Arnold, W., Klein, R. J., Parak, F., Hulin, P., Bergemann, C., Erhardt, W., Wagenpfel, S., Lübbe, A. (2000). Locoregional cancer treatment with magnetic drug targeting. Cancer Res. 60, 6641–6648.Google Scholar
  3. 3.
    Aurich, K., Schwalbe, M., Clement, J. H., Weitschies, W., Buske, N. (2007). Polyaspartate coated magnetite nanoparticles for biomedical applications. J. Magn. Magn. Mater. 311, 1–5.CrossRefGoogle Scholar
  4. 4.
    Fernández-Pacheco, R., Arruebo, M., Marquina, C. I., Ibarra, M. R., Arbiol, J., Santamaría, J. (2006). Highly magnetic silica-coated iron nanoparticles prepared by the arc-discharge method. Nanotechnology 17, 1188–1192.CrossRefGoogle Scholar
  5. 5.
    Arruebo, M., Galán, M., Navascués, N., Téllez, C., Marquina, C., Ibarra, M. R., Santamaría, J. (2006). Development of magnetic nanostructured silica-based materials as potential vectors for drug-delivery applications. Chem. Mater. 18, 1911–1919.CrossRefGoogle Scholar
  6. 6.
    Shinkai, M., Suzuki, M., Iijima, S., Kobayashi, T. (1994). Antibody-conjugated magnetoliposomes for targeting cancer cells and their application in hyperthermia. Biotechnol. Appl. Biochem. 21, 125–137.Google Scholar
  7. 7.
    Shinkai, M. (2002). Functional magnetic particles for medical application. J. Biosci. Bioeng. 94, 606–613.Google Scholar
  8. 8.
    Lübbe, A., Alexiou, C., Bergemann, C. (2001). Clinical applications of magnetic drug targeting. J. Surgical Res. 95, 200–206.CrossRefGoogle Scholar
  9. 9.
    Alexiou, C., Jurgons, R., Schmid, R., Hilpert, A., Bergemann, C., Parak, F., Iro, H. (2005). In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles. J. Magn. Magn. Mater. 293, 389–393.CrossRefGoogle Scholar
  10. 10.
    Pankhurst, Q. A., Connolly, J., Jones, S. K., Dobson, J. (2003). Applications of magnetic nanoparticles in biomedicine. J. Phys. D: Appl. Phys. 36, R167–R181.CrossRefGoogle Scholar
  11. 11.
    Goya, G. F., Grazú, V., Ibarra, M. R. (2007). Magnetic nanoparticles for cancer therapy. Curr. Nanosc. 4, 1–16.CrossRefGoogle Scholar
  12. 12.
    Ritter, J. A., Ebner, A. D., Daniel, K. D., Stewart, K. L. (2004). Application of high gradient magnetic separation principles to magnetic drug targeting. J. Magn. Magn. Mater. 280, 184–201.CrossRefGoogle Scholar
  13. 13.
    Kuznetsov, A. A., Filippov, V. I., Kuznetsov, O. A., Gerlivanov, V. G., Dobrinsky, E. K., Malashin, S. I. (1999). New ferro-carbon adsorbents for magnetically guided transport of anti-cancer drugs. J. Magn. Magn. Mater. 194, 22–30.CrossRefGoogle Scholar
  14. 14.
    Jain, T. K., Morales, M. A., Sahoo, S. K., Leslie-Pelecky, D. L., Labhasetwar, V. (2005). Iron oxide nanoparticles for sustained delivery of anticancer agents. Mol. Pharm. 2, 194–205.CrossRefGoogle Scholar
  15. 15.
    Finotelli, P. V., Morales, M. A., Rocha-Leão, M. H., Baggio-Saitovitch, E. M., Rossi, A. M. (2004). Magnetic studies of iron (III) nanoparticles in alginate polymer for drug delivery applications. Mater. Sci. Eng.: C 24, 625–629.CrossRefGoogle Scholar
  16. 16.
    Neuberger, T., Schopf, B., Hofmann, H., Hofmann, M., von Rechenberg, B. (2005). Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system. J. Magn. Magn. Mater. 293, 483–496.CrossRefGoogle Scholar
  17. 17.
    Gupta, A. K., Gupta, M. (2005). Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26, 3995–4021.CrossRefGoogle Scholar
  18. 18.
    Li, L., Chen, D., Zhang, Y., Deng, Z., Ren, X., Meng, X., Tang, F., Ren, J., Zhang, L. (2007) Magnetic and fluorescent multifunctional chitosan nanoparticles as a smart drug delivery system. Nanotechnology 18, 405102–405107.CrossRefGoogle Scholar
  19. 19.
    Muller, R. H., Keck, C. M. (2004). Challenges and solutions for the delivery of biotech drugs – a review of drug nanocrystal technology and lipid nanoparticles. J. Biotech. 113, 151–170.CrossRefGoogle Scholar
  20. 20.
    Berry, C. C., Curtis, A. S. G. (2003). Functionalisation of magnetic nanoparticles for applications in biomedicine. J. Phys. D: Appl. Phys. 36, R198–R206.CrossRefGoogle Scholar
  21. 21.
    Zhang, J. L., Srivastava, R. S., Misra, R. D. K. (2007). Core-shell magnetite nanoparticles surface encapsulated with smart stimuli-responsive polymer: synthesis, characterization, and LCST of viable drug-targeting delivery system. Langmuir 23, 6342–6351.CrossRefGoogle Scholar
  22. 22.
    Arruebo, M., Fernández-Pacheco, R., Ibarra, M. R., Santamaría, J. (2007). Magnetic Nanoparticles for Drug Delivery. Nanotoday 2, 22–32.Google Scholar
  23. 23.
    Xu, Z. P., Hua Zeng, Q., Lu, G. Q., Bing Yu, A. (2006). Inorganic nanoparticles as carriers for efficient cellular delivery. Chem. Eng. Sci. 61, 1027–1040.CrossRefGoogle Scholar
  24. 24.
    Liu, Y. L., Hsu, C. Y., Wang, M. L., Chen, H. S. (2003). A novel approach of chemical functionalization on nano-scaled silica particles. Nanotechnology 14, 813–819.CrossRefGoogle Scholar
  25. 25.
    Spange, S. (2000). Silica surface modification by cationic polymerization and carbenium intermediates. Prog. Polym. Sci. 25, 781–849.CrossRefGoogle Scholar
  26. 26.
    Moghimi, S. M. (2002). Chemical camouflage of nanospheres with a poorly reactive surface: towards development of stealth and target-specific nanocarriers. Biochim. Biophys. Acta 1590, 131–139.CrossRefGoogle Scholar
  27. 27.
    Gref, R., Domb, A., Quellec, P., Blunck, T., Muller, R. H., Verbavatz, J. M., Langer, R. (1995). The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres. Adv. Drug Deliv. Rev. 16, 215–233.CrossRefGoogle Scholar
  28. 28.
    Rudge, S., Peterson, C., Vessely, C. (2001). Adsorption and desorption of chemotherapeutic drugs from a magnetically targeted carrier (MTC). J. Contr. Release 74, 335–340.CrossRefGoogle Scholar
  29. 29.
    Flores, G. A., Liu, J. (2002). In vitro blockage of a simulated vascular system using magnetorheological fluids as a cancer therapy. Eur. Cell. Mater. 3, 9–11.Google Scholar
  30. 30.
    Yellen, B. B., Forbes, Z. G., Halverson, D. S., Fridman, G., Barbee, K. A., Chorny, M., Levy, R., Friedman, G. (2005). Targeted drug delivery to magnetic implants for therapeutic applications. J. Magn. Magn. Mater. 293, 647–654.CrossRefGoogle Scholar
  31. 31.
    Avilés, M. O., Ebner, A. D., Chen, H., Rosengart, A. J., Kaminski, M. D., Ritter, J. A. (2005). Theoretical analysis of a transdermal ferromagnetic implant for retention of magnetic drug carrier particles. J. Magn. Magn. Mater. 293, 605–615.CrossRefGoogle Scholar
  32. 32.
    Avilés, M. O., Chen, H., Ebner, A. D., Rosengart, A. J., Kaminski, M. D., Ritter, J. A. (2007). In vitro study of ferromagnetic stents for implant assisted-magnetic drug targeting. J. Magn. Magn. Mater. 311, 306–311.CrossRefGoogle Scholar
  33. 33.
    Fernández-Pacheco, R., Ibarra, M. R., Valdivia, J. G., Marquina, C. I., Serrate, D., Romero, M. S., Gutiérrez, M., Arbiol, J. (2005). Carbon Coated Magnetic nanoparticles for local drug delivery using magnetic implants. Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Vol 1. NSTI Publications, Danville (USA), pp.144–147.Google Scholar
  34. 34.
    Fernández-Pacheco, R., Marquina, C. I., Valdivia, J. G., Gutiérrez, M., Romero, M. S., Cornudella, R., Laborda, A., Viloria, A., Higuera, T., García, A., García de Jalôn, J. A., Ibarra, M. R. (2007). Magnetic nanoparticles for local drug delivery using magnetic implants. J. Magn. Magn. Mater. 311, 318–322.CrossRefGoogle Scholar
  35. 35.
    Chellat, F., Merhi, Y., Moreau, A., Yahia, L. (2005). Therapeutic potential of nanoparticulate systems for macrophage targeting. Biomaterials 26, 7260–7275.CrossRefGoogle Scholar

Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Rodrigo Fernández-Pacheco
    • 1
  • J. Gabriel Valdivia
    • 1
  • M. Ricardo Ibarra
    • 1
  1. 1.Instituto Universitario de Investigación en Nanociencia de Aragón (INA), Instituto de Ciencia de Materiales de Aragón (ICMA)Universidad de Zaragoza-CSICZaragozaSpain

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