Advertisement

Murine Antigen-Induced Arthritis

  • Wim B. van den Berg
  • Leo A. B. Joosten
  • Peter L. E. M. van Lent
Part of the Methods in Molecular Medicine book series (MIMM, volume 136)

Abstract

Antigen induced arthritis is a unilateral T-cell driven model caused by direct injection of an antigen into the knee joint of a FCA preimmunized animal. The chronicity is determined by antigen retention in avascular structures of the joint through charge mediated binding or antibody mediated trapping. Cationicity of the antigen is a prerequisite in this model in the mouse and commercial mBSA is a suitable antigen. Cartilage erosive character is strongly enhanced in the presence of marked antibody titer. Concomitant boosting of the immune response with Bordetella pertussis adds to this. T-cell mediated flares can be induced by local or systemic rechallenge with low dose antigen, and display a strong erosive phenotype.

Key Words

T-cell arthritis cartilage destruction antibodies flares 

References

  1. 1.
    Dumonde, D. C. and Glynn, L. E. (1962) The production of arthritis in rabbits by an immunological reaction to fibrin. Br. J. Exp. Pathol., 43, 373–383.PubMedGoogle Scholar
  2. 2.
    Brackertz, D., Mitchell, G. F., and Mackay, I. R. (1977) Antigen-induced arthritis in mice. I. Induction of arthritis in various strains of mice. Arthritis Rheum. 20, 841–850.PubMedCrossRefGoogle Scholar
  3. 3.
    Cooke, T. D. V., Hird, E. R., Ziff, M., and Jasin, H. E. (1972) The pathogenesis of chronic inflammation in experimental antigen induced arthritis. J. Exp. Med. 135, 322–338.CrossRefGoogle Scholar
  4. 4.
    Van den Berg, W. B., van Beusekom, H. J., van de Putte, L. B. A., Zwarts, W. A., and van der Sluis, M. (1982) Antigen handling in antigen-induced arthritis in mice: an autoradiographic and immunofluorescence study using whole joint sections. Am. J. Pathol. 108, 9–16.PubMedGoogle Scholar
  5. 5.
    Van den Berg, W. B., van de Putte, L. B. A., Zwarts, W. A., and Joosten, L. A. B. (1984) Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice. J. Clin. Invest. 74, 1850–1859.PubMedCrossRefGoogle Scholar
  6. 6.
    Van den Berg, W. B. and van de Putte, L. B. A. (1985) Electrical charge of the antigen determines its localization in the mouse knee joint: deep penetration of cationic BSA in hyaline articular cartilage. Am. J. Pathol. 121, 224–234.PubMedGoogle Scholar
  7. 7.
    Mertz, A. K. H., Batsford, S. R., Curschella, E., Kist, M. J., and Gondolf, K. B. (1991) Cationic Yersinia antigen-induced chronic allergic arthritis in rats. A model for reactive arthritis in human. J. Clin. Invest. 87, 632–642.CrossRefGoogle Scholar
  8. 8.
    Matsumoto, I., Maccioni, M., Lee, D. M., et al. (2002) How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat. Immunol. 3, 360–365.PubMedCrossRefGoogle Scholar
  9. 9.
    Kruijsen, M. W. M., van den Berg, W. B., van de Putte, L. B. A., and van den Broek, W. J. M. (1981) Detection and quantification of experimental joint inflammation in mice by measurement of 99 mTc-pertechnetate uptake. Agents Actions 11, 640–642.PubMedCrossRefGoogle Scholar
  10. 10.
    Van Meurs, J. B. J., van Lent, P. L. E. M., Singer, I. I., Bayne, E. K., van de Loo, F. A. J., and van den Berg, W. B. (1998) IL-1ra prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis. Arthritis Rheum. 41, 647–656.PubMedCrossRefGoogle Scholar
  11. 11.
    Van Meurs, J. B. J., van Lent, P. L. E..M., Holthuysen, A. E. M., Singer, I. I., Bayne, E. K., and van den Berg, W. B. (1999) Kinetics of aggrecanase and metalloproteinase induced neoepitopes in various stages of cartilage destruction in murine arthritis. Arthritis Rheum. 42, 1128–1139.PubMedCrossRefGoogle Scholar
  12. 12.
    Van Meurs, J. B. J., van Lent, P. L. E. M., Stoop, R., et al. (1999) Cleavage of aggrecan at Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: A pivotal role for stromelysin-1 in MMP activity. Arthritis Rheum. 10, 2074–2084.CrossRefGoogle Scholar
  13. 13.
    Van den Berg, W. B., Kruijsen, M. W. M., and van de Putte, L. B. A. (1982) The mouse patella assay: an easy method of quantitating articular cartilage chondrocyte function in vivo and in vitro. Rheumatol. Int. 1,165–169.CrossRefGoogle Scholar
  14. 14.
    Van de Loo, A. A. J., Arntz, O. J., Otterness, I. G., and van den Berg, W. B. (1992) Protection against cartilage proteoglycan synthesis inhibition by antiinterleukin 1 antibodies in experimental arthritis. J. Rheumatol. 19, 348–356.PubMedGoogle Scholar
  15. 15.
    Van de Loo, A. A. J., Joosten, L. A. B., van Lent, P. L. E. M., Arntz, O. J., and van den Berg, W. B. (1995) Role of Interleukin-1, Tumor Necrosis Factor I and Interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ cytokine blocking in murine antigen-and zymosan-induced arthritis. Arthritis Rheum. 38, 164–172.PubMedCrossRefGoogle Scholar
  16. 16.
    Lens, J. W., van den Berg, W. B., and van de Putte, L. B. A. (1984) Flare-up of antigen-induced arthritis in mice after challenge with intravenous antigen. Studies on the characteristics of and mechanisms involved in the reaction. Clin. Exp. Immunol. 55, 287–294.PubMedGoogle Scholar
  17. 17.
    Lens, J. W., van den Berg, W. B., van de Putte, L. B. A., Berden, J. H. M., and Lems, S. P. M. (1984) Flare-up of antigen-induced arthritis in mice after challenge with intravenous antigen: effects of pretreatment with cobra venom factor and antilymphocyte serum. Clin. Exp. Immunol. 57, 520–528.PubMedGoogle Scholar
  18. 18.
    Lens, J. W., van den Berg, W. B., van de Putte, L. B. A., and Zwarts, W. A. (1986) Flare-up of antigen induced arthritis in mice after challenge with intravenous antigen: kinetic of antigen in the circulation and localization of antigen in the arthritic and noninflamed joint. Arthritis Rheum. 29, 665–674.PubMedCrossRefGoogle Scholar
  19. 19.
    Van Lent, P. L. E. M., Nabbe, K., Blom, A. B., et al. (2001) Role of activatory Fcγ RI and Fcγ RIII and inhibitory Fcγ RII in inflammation and cartilage destruction during experimental antigen-induced arthritis. Am. J. Pathol. 159, 2309–232PubMedCrossRefGoogle Scholar
  20. 20.
    Nabbe, K. C. A. M., Blom, A. B., Holthuysen, A. E. M., et al. (2003) Coordinate expression of activating FcγRI and III and inhibiting FcγRII in the determination of joint inflammation and cartilage destruction during immune complex-mediated arthritis. Arthritis Rheum. 48, 255–265PubMedCrossRefGoogle Scholar
  21. 21.
    Staite, N. D., Richard, K. A., Aspar, D. G., Franz, K. A., Galinet, L. A., and Dunn, C. J. (1990) Induction of an acute erosive monoarticular arthritis in mice by interleukin-1 and methylated bovine serum albumin. Arthritis Rheum. 33, 253–260.PubMedCrossRefGoogle Scholar
  22. 22.
    Van de Loo, A. A. J., Arntz, O.J., Bakker, A. C., van Lent, P. L. E. M., Jacobs, M.J.M., and van den Berg, W. B. (1995) Role of Interleukin-1 in antigen-induced exacerbations of murine arthritis. Am. J. Pathol. 146, 239–249.PubMedGoogle Scholar
  23. 23.
    Koenders, M. I., Lubberts, E., Oppers-Walgreen, B., et al. (2005) Blocking of IL-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and IL-1. Am. J. Pathol. 167, 141–149.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc., Totowa, NJ 2007

Authors and Affiliations

  • Wim B. van den Berg
    • 1
  • Leo A. B. Joosten
    • 2
  • Peter L. E. M. van Lent
    • 2
  1. 1.Radboud University Nijmegen Medical CentreNijmegenThe Netherlands
  2. 2.Rheumatology Research and Advanced TherapeuticsRadboud University Nijmegen Medical CentreNijmegenThe Netherlands

Personalised recommendations