Protocol

Hepatitis C

Volume 510 of the series Methods in Molecular Biology™ pp 329-336

Measuring HCV Infectivity Produced in Cell Culture and In Vivo

  • Brett D. LindenbachAffiliated withSection of Microbial Pathogenesis, Yale University School of Medicine

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Abstract

Recently described systems for efficiently growing HCV in cell culture provide powerful new tools with which to dissect the life cycle of this important human pathogen. This chapter describes methods for measuring the infectivity of HCV produced in cell culture or recovered from animals experimentally infected with the cell culture–produced virus.

Key Words

Hepatitis C virus HCV titer infectivity assay