Interpreting Microarray Results With Gene Ontology and MeSH

  • John D. Osborne
  • Lihua (Julie) Zhu
  • Simon M. Lin
  • Warren A. Kibbe
Part of the Methods in Molecular Biology™ book series (MIMB, volume 377)


Methods are described to take a list of genes generated from a microarray experiment and interpret these results using various tools and ontologies. A workflow is described that details how to convert gene identifiers with SOURCE and MatchMiner and then use these converted gene lists to search the gene ontology (GO) and the medical subject headings (MeSH) ontology. Examples of searching GO with DAVID, EASE, and GOMiner are provided along with an interpretation of results. The mining of MeSH using high-density array pattern interpreter with a set of gene identifiers is also described.

Key Words

Microarray GO MeSH protocol DAVID HAPI SOURCE MatchMiner Interpret 


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Copyright information

© Humana Press Inc., Totowa, NJ 2007

Authors and Affiliations

  • John D. Osborne
    • 1
  • Lihua (Julie) Zhu
    • 1
  • Simon M. Lin
    • 1
  • Warren A. Kibbe
    • 1
  1. 1.Robert H. Lurie Comprehensive Cancer CenterNorthwestern UniversityChicago

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