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Designing Experiments for High-Throughput Protein Expression

  • Stephen P. Chambers
  • Susanne E. Swalley
Part of the Methods in Molecular Biology book series (MIMB, volume 498)

Summary

The advent of high-throughput protein production and the vast amount of data it is capable of generat ing has created both new opportunities and problems. Automation and miniaturization allow experimen tation to be performed more efficiently, justifying the cost involved in establishing a high-throughput platform. These changes have also magnified the need for effective statistical methods to identify trends and relationships in the data. The application of quantitative management tools to this process provides the means of ensuring maximum efficiency and productivity.

Key words:

Protein expression optimization Quantitative analysis Experimental design Screening Statistics 

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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Stephen P. Chambers
    • 1
  • Susanne E. Swalley
    • 1
  1. 1.Gene ExpressionVertex PharmaceuticalsCambridgeUSA

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