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A Novel Preclinical Rat Model of Alzheimer’s Disease

  • Karim A. AlkadhiEmail author
Protocol
Part of the Neuromethods book series (NM, volume 152)

Abstract

We have developed a novel rat model that correlates with seemingly normal individuals who are predisposed (at-risk) to developing Alzheimer’s disease (AD). This work summarizes the findings we have reported on the effect of chronic psychosocial stress in this at-risk rat model of AD. Behavioral (learning and memory tests), electrophysiological (evoked LTP) and molecular (determining protein levels of signaling molecules) studies suggest that even mild chronic psychosocial stress can converts this seemingly normal rat into one showing clear AD phenotype. It is well known that vast individual variations exist in the time of onset and severity of the sporadic type of AD. Therefore, a patient-related external factor must be assumed to play a significant role in the development of the sporadic type of the disease. Since stress is increasingly recognized as an external factor in the development of AD, we tested the effect of mild psychosocial stress on our at-risk model.

Key words

Rat subclinical AD model Amyloid-beta Learning and memory Signaling molecules Synaptic plasticity 

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© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Department of Pharmacological and Pharmaceutical Sciences, College of PharmacyUniversity of HoustonHoustonUSA

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