Pushing the Envelope: Advancement of ADCs Outside of Oncology

  • Michael J. McPhersonEmail author
  • Adrian D. Hobson
Part of the Methods in Molecular Biology book series (MIMB, volume 2078)


The majority of ADCs in preclinical and clinical development are for oncology indications where cytotoxic payloads are targeted to antigen-expressing cancer cells. However, the modulation of pathogenic cellular activity via ADC-mediated delivery of bioactive small molecules is also an attractive concept for non-oncology indications leading to an expanded application of the technology. Here we summarize those ADCs that have been described so far for non-oncology applications and which cover a variety of payload mechanisms beyond cell killing, from early in vitro proof-of-concept experiments to clinical trials. As our understanding of ADC technology continues to grow, it is anticipated that the development of ADCs as therapeutics for disease areas outside of oncology will also increase.

Key words

Non-oncology ADC Anti-inflammatory Glucocorticoid Antibiotic Payload Antibody drug conjugate Inflammatory disease 


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© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Abbvie Global BiologicsAbbVie Bioresearch CenterWorcesterUSA

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