Homology Modeling of P2X Receptors

  • Anastasios Stavrou
  • Sudad Dayl
  • Ralf SchmidEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 2041)


Since the X-ray structure of the zebra fish P2X4 receptor in the closed state was published in 2009 homology modeling has been used to generate structural models for P2X receptors. In this chapter, we outline how to use the MODELLER software to generate such structural models for P2X receptors whose structures have not been solved yet.

Key words

Homology modeling Protein structure prediction MODELLER software P2X receptor Ion channel 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Department of Molecular and Cell BiologyUniversity of LeicesterLeicesterUK
  2. 2.Department of Chemistry, College of ScienceUniversity of BaghdadBaghdadIraq
  3. 3.Leicester Institute of Structural and Chemical Biology (LISCB)University of LeicesterLeicesterUK

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