Y-Shaped Maze to Test Spontaneous Object Recognition and Temporal Order Memory After Traumatic Brain Injury
Traumatic brain injury (TBI) is one of the most frequent causes of brain damage. Cognitive deficits have been reported in the literature after mild-to-severe TBI affecting memory, language, executive functions, attention, and information processing speed. In this chapter, we describe a method to characterize cognitive impairment in rats following TBI of various intensities. The focus will be on spontaneous object recognition and temporal order memory in rats. These tests are performed in a Y-shaped maze. We have previously identified using this method persistent spontaneous object recognition and temporal order memory deficits following mild-to-moderate TBI in the animals up to 35-day postinjury.
Key wordsY-maze Traumatic brain injury Temporal order memory Object recognition memory Memory deficits