Neurological Exam in Rats Following Stroke and Traumatic Brain Injury
Using the appropriate model for testing neurological symptoms in rats is essential for the assessment of functional outcome. A number of tests have been developed to quantify the severity of neurological deficits. These tests should meet criteria such as validity, specificity, sensitivity, and utility. Although analysis of motor function shows homology in primates and rodents, the total neurological exam scores may not always reflect the clinical outcome. Therefore, the selection of the appropriate tests has critical importance when evaluating therapeutic strategies. This chapter describes Toklu’s modified neurological exam score method which can be used practically to assess neurological symptoms following traumatic brain injury (TBI) and stroke. The method is a combination of balance, muscle strength, coordination, and reflex.
Key wordsNeurological exam Neurological score Rat Brain injury Stroke Trauma
This modified scoring was first used in the Ph.D. thesis of Hale Toklu with her advisor Prof. Meral Keyer-Uysal. The authors also would like to thank Professors Goksel Sener, Berrak Yegen, Gul Ayanoglu Dulger, Tayfun Hakan, and Nihal Tumer for their supervision/contribution in brain injury studies with TBI models.
The authors are grateful to Prof. Christopher Vallandingham for language editing and proofreading.
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