Preparation and Characterization of Solid Lipid Nanoparticles-Based Gel for Topical Delivery

  • Vandana B. PatravaleEmail author
  • Amit G. Mirani
Part of the Methods in Molecular Biology book series (MIMB, volume 2000)


Solid lipid nanoparticles (SLNs) have been extensively investigated for effective delivery of both hydrophilic and lipophilic drugs by topical route. There are several scalable techniques for the preparation of SLNs such as homogenization, microemulsion template, and solvent emulsification diffusion. This chapter describes step-wise methodology for the preparation and characterization of SLNs using solvent emulsification diffusion method. Tretinoin, a lipophilic entity, was chosen as a model drug. The critical aspects and the important interpretations with respect to the preparation and characterization of SLNs are reported in “Notes” section.

Key words

Solvent-emulsification diffusion Solid lipid nanoparticles Tretinoin Topical route 


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Pharmaceutical Sciences and TechnologyInstitute of Chemical TechnologyMumbaiIndia

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