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Leveraging Big Data to Transform Drug Discovery

  • Benjamin S. Glicksberg
  • Li Li
  • Rong Chen
  • Joel Dudley
  • Bin ChenEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1939)

Abstract

The surge of public disease and drug-related data availability has facilitated the application of computational methodologies to transform drug discovery. In the current chapter, we outline and detail the various resources and tools one can leverage in order to perform such analyses. We further describe in depth the in silico workflows of two recent studies that have identified possible novel indications of existing drugs. Lastly, we delve into the caveats and considerations of this process to enable other researchers to perform rigorous computational drug discovery experiments of their own.

Key words

Systems pharmacology Drug discovery Big data Electronic medical records Clinical informatics Bioinformatics Drug repurposing Drug repositioning Gene expression data Pharmacogenomics 

Notes

Acknowledgments

The research is supported by R21 TR001743, U24 DK116214, and K01 ES028047 (to BC). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Benjamin S. Glicksberg
    • 1
    • 2
  • Li Li
    • 2
    • 3
  • Rong Chen
    • 2
    • 3
  • Joel Dudley
    • 2
  • Bin Chen
    • 1
    • 4
    • 5
    Email author
  1. 1.Bakar Computational Health Sciences InstituteUniversity of CaliforniaSan FranciscoUSA
  2. 2.Department of Genetics and Genomic SciencesInstitute of Next Generation Healthcare, Icahn School of Medicine at Mount SinaiNew YorkUSA
  3. 3.Sema4, A Mount Sinai VentureStamfordUSA
  4. 4.Department of Pediatrics and Human DevelopmentMichigan State UniversityGrand RapidsUSA
  5. 5.Department of Pharmacology and ToxicologyMichigan State UniversityGrand RapidsUSA

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