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Rare Cell Type Detection

  • Lan JiangEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1935)

Abstract

High-throughput single-cell technologies have great potential to discover new cell types. Here, we present a novel computational method, called GiniClust (Jiang et al., Genome Biol 17(1):144, 2016), to overcome the challenge of detecting rare cell types that are distinct from a large population.

Key words

Clustering Single-cell analysis RNA-seq qPCR Gini index Rare cell type 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Howard Hughes Medical InstituteBoston Children’s HospitalBostonUSA
  2. 2.Program in Cellular and Molecular MedicineBoston Children’s HospitalBostonUSA
  3. 3.Division of Hematology/Oncology, Department of PediatricsBoston Children’s HospitalBostonUSA

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