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Modeling Embryonic Cleavage Patterns

  • Dmitry Ershov
  • Nicolas MincEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1920)

Abstract

The division patterns of early invertebrate and vertebrate embryos are key to the specification of cell fates and embryo body axes. We here describe a generic computational modeling method to quantitatively test mechanisms which specify successive division position and orientation of eggs and early blastomeres in 3D. This approach should serve to motivate and guide future experimental work on the mechanisms controlling early embryo morphogenesis.

Key words

Early embryos Division positioning Microtubules Asters Cell shape Maternal domain Yolk 

Notes

Acknowledgments

We thank Anaëlle Pierre and Benjamin Blanchard for their initial contribution to the model. This research was supported by the CNRS and grants from the “Mairie de Paris emergence” program, the FRM “amorçage” grant AJE20130426890, and the European Research Council (CoG Forcaster N° 647073).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Institut Jacques Monod, CNRS UMR7592ParisFrance
  2. 2.Université Paris DiderotParisFrance

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