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In Vivo Models of Rheumatoid Arthritis

  • Bettina Grötsch
  • Aline BozecEmail author
  • Georg Schett
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1914)

Abstract

Rheumatoid arthritis (RA) models in mice induced by immunization enable the analyses of molecular mechanism involved in disease development, progression, and resolution of inflammation. Here, we describe three different models mimicking clinic symptoms of human rheumatoid arthritis, which could be transferable to any genetically modified mouse. We will present the protocol for collagen-induced arthritis (CIA), K/BxN serum-induced arthritis (SIA), and the antigen-induced arthritis (AIA) models. To do so, we will detail their way of induction but also how to analyze RA clinical score and pathology characterization. Finally, we will briefly discuss the main characteristics and disadvantages of all three models.

Key words

Rheumatoid arthritis Collagen-induced arthritis K/BxN serum-induced arthritis Antigen-induced arthritis 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Medicine 3, Rheumatology and ImmunologyUniversity Hospital ErlangenErlangenGermany

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