Circulating Cell-Free DNA in Physical Activities

  • Leydi Natalia Vittori
  • Andrea Tarozzi
  • Pasqualino Maietta Latessa
Part of the Methods in Molecular Biology book series (MIMB, volume 1909)


The interest about circulating cell-free DNA (cfDNA) concentration increased from several years because of its correlation with various conditions like osteoarthritis, cancers, stroke, and sepsis; recently it has become an important marker for overtraining syndrome or performance diagnostics.

Several studies have demonstrated that cfDNA increases in vigorous and exhausting exercise but also endurance exercise. Acute effect of exercise on cfDNA concentration seems to be correlated to stress factor, while chronic effect is associated with necrosis and apoptosis.

The intensity and duration seem to have effects on the variation of cfDNA concentration that is strongly correlated with other metabolic markers like acid lactate and creatine kinase, recognized as markers of muscle damage. Variation of cfDNA value could be used to predict overtraining syndrome.

Key words

Physical activities Acute exercise Chronic exercise Intensity cell-free plasma DNA Inflammation Overtraining 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Leydi Natalia Vittori
    • 1
  • Andrea Tarozzi
    • 1
  • Pasqualino Maietta Latessa
    • 1
  1. 1.Department for Life Quality StudiesAlma Mater Studiorum—University of BolognaBolognaItaly

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