FOXO Transcription Factors pp 231-238 | Cite as
Hydra as Model to Determine the Role of FOXO in Longevity
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Abstract
In non-senescent Hydra, continuously high activity of transcription factor FOXO contributes to continuous stem cell proliferation. Here, we describe how genetic manipulation of Hydra polyps using embryo-microinjection allows uncovering the role of FOXO in coordinating both stem cell proliferation and antimicrobial peptide0073, effector molecules of the innate immune system, and regulators of the microbiome.
Key words
Hydra Stem cells Aging Microbiome FOXO Embryo microinjection Reporter gene constructs Antimicrobial peptides (AMPs)Notes
Acknowledgment
This work was supported by the Deutsche Forschungsgemeinschaft (DFG) (CRC1182 “Origin and Function of Metaorganisms,” DFG grant BO 848/17-1, and grants from the DFG Cluster of Excellence program “Inflammation at Interfaces”). The author gratefully appreciates support from the Canadian Institute for Advanced Research (CIFAR).
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