Database and Bioinformatic Analysis of BCL-2 Family Proteins and BH3-Only Proteins

  • Abdel AouacheriaEmail author
  • Vincent Navratil
  • Christophe Combet
Part of the Methods in Molecular Biology book series (MIMB, volume 1877)


BCL-2 proteins correspond to a structurally, functionally, and phylogenetically heterogeneous group of regulators that play crucial roles in the life and death of animal cells. Some of these regulators also represent therapeutic targets in human diseases including cancer. In the omics era, there is great need for easy data retrieval and fast analysis of the molecular players involved in cell death. In this chapter, we present generic and specific computational resources (such as the reference database BCL2DB) as well as bioinformatics tools that can be used to investigate BCL-2 homologs and BH3-only proteins.

Key words

Databases Bioinformatics Omics Structure–function relationships Protein domains Protein motifs BCL-2 BH3 Apoptosis Cell death 



This work was supported by CNRS and Montpellier University. We also acknowledge financial support from the Fondation ARC (AA) and Ligue Contre le Cancer ComitÕ du Gard (AA).


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Abdel Aouacheria
    • 1
    Email author
  • Vincent Navratil
    • 2
  • Christophe Combet
    • 3
  1. 1.ISEM, Institut des Sciences de l’Evolution de MontpellierUniversité de Montpellier, UMR 5554, CNRS, IRD, EPHEMontpellierFrance
  2. 2.PRABI, Rhône Alpes Bioinformatics Center, UCBL, Lyon1Université de LyonLyonFrance
  3. 3.Centre de Recherche en Cancérologie de LyonUMR Inserm U1052, CNRS 5286, Université Claude Bernard Lyon 1, Centre Léon BérardLyonFrance

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