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Cell Cycle Dynamics in Glioma Cancer Stem Cells

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Brain Tumor Stem Cells

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1869))

Abstract

Cancer stem cells, sometimes referred to as tumor initiating cells, play pivotal roles in tumor initiation, progression, metastasis, resistance to therapy, and relapse. Understanding how these populations of cells expand in response to a host of conditions is critical in determining effective cancer therapeutics. A defining feature of cancer stem cells is the ability to switch between modes of quiescence and symmetric/asymmetric division to protect and conserve the population, this feature is traditionally reserved for normal adult stem cell populations. Understanding how the core cell cycle machinery responds to external cues to drive symmetric/asymmetric division vs. quiescence will reveal fundamental information about how cancer stem cell populations survive and expand. This chapter will describe methods to study the cell cycle dynamics in brain cancer stem cell populations and how they compare to the other populations in a tumor.

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Author information

Authors and Affiliations

  1. Department of Biological Sciences, University of Windsor, Windsor, ON, Canada

    Ingrid Qemo & Lisa A. Porter

Authors
  1. Ingrid Qemo
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  2. Lisa A. Porter
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Corresponding author

Correspondence to Lisa A. Porter .

Editor information

Editors and Affiliations

  1. Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada

    Sheila K. Singh

  2. Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada

    Chitra Venugopal

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© 2019 Springer Science+Business Media, LLC, part of Springer Nature

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Qemo, I., Porter, L.A. (2019). Cell Cycle Dynamics in Glioma Cancer Stem Cells. In: Singh, S., Venugopal, C. (eds) Brain Tumor Stem Cells. Methods in Molecular Biology, vol 1869. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8805-1_11

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  • DOI: https://doi.org/10.1007/978-1-4939-8805-1_11

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8804-4

  • Online ISBN: 978-1-4939-8805-1

  • eBook Packages: Springer Protocols

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