An Integrative Approach to Virus–Host Protein–Protein Interactions

  • Helen V. Cook
  • Lars Juhl JensenEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1819)


Since cell regulation and protein expression can be dramatically altered upon infection by viruses, studying the mechanisms by which viruses infect cells and the regulatory networks they disrupt is essential to understanding viral pathogenicity. This line of study can also lead to discoveries about the workings of host cells themselves. Computational methods are rapidly being developed to investigate viral-host interactions, and here we highlight recent methods and the insights that they have revealed so far, with a particular focus on methods that integrate different types of data. We also review the challenges of working with viruses compared with traditional cellular biology, and the limitations of current experimental and informatics methods.

Key words

Viruses Virus–host interactions Databases Bioinformatics Machine learning Orthology Host prediction Viral evolution Coevolution PPI networks Network rewiring 



Thanks to Lars Juhl Jensen for his early review of this chapter and constructive comments. Thanks also to Alberto Santos and Louise von Stechow for their thorough feedback.


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Authors and Affiliations

  1. 1.Novo Nordisk Center for Protein ResearchUniversity of CopenhagenCopenhagenDenmark

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