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Exploring Dynamics and Noise in Gonadotropin-Releasing Hormone (GnRH) Signaling

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Computational Cell Biology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1819))

Abstract

Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. FSH and LH control steroidogenesis and gametogenesis in the gonads so GnRH mediates control of reproduction by the central nervous system. GnRH is secreted in short pulses and the effects of GnRH on its target cells are dependent on the dynamics of these pulses. Here we provide a brief overview of the signaling network activated by GnRH with emphasis on the use of high content imaging for their examination. We also describe computational approaches that we have used to simulate GnRH signaling in order to explore dynamics, noise, and information transfer in this system.

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    Authors and Affiliations

    1. EPSRC Centre for Predictive Modeling in Healthcare, University of Exeter, Exeter, UK

      Margaritis Voliotis & Krasimira Tsaneva-Atanasova

    2. Department of Mathematics and Living Systems Institute, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK

      Margaritis Voliotis & Krasimira Tsaneva-Atanasova

    3. Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Bristol, UK

      Kathryn L. Garner, Hussah Alobaid & Craig A. McArdle

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    1. Margaritis Voliotis
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    2. Kathryn L. Garner
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    3. Hussah Alobaid
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    4. Krasimira Tsaneva-Atanasova
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    5. Craig A. McArdle
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    Correspondence to Craig A. McArdle .

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    Editors and Affiliations

    1. NNF Center for Protein Research, University of Copenhagen, Copenhagen, Denmark

      Louise von Stechow

    2. Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark

      Alberto Santos Delgado

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    Voliotis, M., Garner, K.L., Alobaid, H., Tsaneva-Atanasova, K., McArdle, C.A. (2018). Exploring Dynamics and Noise in Gonadotropin-Releasing Hormone (GnRH) Signaling. In: von Stechow, L., Santos Delgado, A. (eds) Computational Cell Biology. Methods in Molecular Biology, vol 1819. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8618-7_19

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