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Approaches for Assessing Olfaction in Children with Autism Spectrum Disorder

  • Hirokazu KumazakiEmail author
  • Masako Okamoto
  • Sho Kanzaki
  • Ken-ichi Okada
  • Masaru Mimura
  • Yoshio Minabe
  • Mitsuru Kikuchi
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1820)

Abstract

Olfactory traits in individuals with autism spectrum disorder (ASD) are considered the strongest predictors of social impairment. Compared to other sensory abnormalities, olfactory abnormalities in individuals with ASD are poorly understood. In this chapter, we provide an overview of the current assessment in individuals with ASD. Several confounding factors have to be considered when conducting research on olfaction in individuals with ASD. Qualitative measures of olfaction contain only limited information about the olfactory stimuli. In addition, little systematic information is available about individual’s actual uses of olfaction in daily life. Only a limited number of experimental studies have performed quantitative measurements of olfactory abnormalities in ASD. Therefore, clarifying the relationship between olfactory traits and the influence of real-life situations in a laboratory setting is very difficult. Some new methodologies for measuring olfactory traits are gradually becoming available. New methods that reveal important links between ASD and olfactory traits should be developed in the future.

Key words

Autism spectrum disorders Olfactory Quantitative Qualitative Real-life situations 

References

  1. 1.
    Leekam SR, Nieto C, Libby SJ, Wing L, Gould J (2007) Describing the sensory abnormalities of children and adults with autism. J Autism Dev Disord 37(5):894–910.  https://doi.org/10.1007/s10803-006-0218-7 CrossRefPubMedGoogle Scholar
  2. 2.
    Tomchek SD, Dunn W (2007) Sensory processing in children with and without autism: a comparative study using the short sensory profile. Am J Occup Ther 61(2):190–200.  https://doi.org/10.5014/ajot.61.2.190 CrossRefPubMedGoogle Scholar
  3. 3.
    American Psychiatric Association (APA) (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington, pp 5–25CrossRefGoogle Scholar
  4. 4.
    Schoen SA, Miller LJ, Brett-Green BA, Nielsen DM (2009) Physiological and behavioral differences in sensory processing: a comparison of children with autism spectrum disorder and sensory modulation disorder. Front Integr Neurosci 3:29.  https://doi.org/10.3389/neuro.07.029.2009 CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Bennetto L, Kuschner ES, Hyman SL (2007) Olfaction and taste processing in autism. Biol Psychiatry 62(9):1015–1021.  https://doi.org/10.1016/j.biopsych.2007.04.019 CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Hubbard KL, Anderson SE, Curtin C, Must A, Bandini LG (2014) A comparison of food refusal related to characteristics of food in children with autism spectrum disorder and typically developing children. J Acad Nutr Diet 114(12):1981–1987.  https://doi.org/10.1016/j.jand.2014.04.017 CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Luisier A-C, Petitpierre G, Ferdenzi C, Clerc Bérod A, Giboreau A, Rouby C et al (2015) Odor perception in children with autism spectrum disorder and its relationship to food neophobia. Front Psychol 6:1830.  https://doi.org/10.3389/fpsyg.2015.01830 CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Hilton C, Graver K, LaVesser P (2007) Relationship between social competence and sensory processing in children with high functioning autism spectrum disorders. Res Autism Spectr Disord 1(2):164–173.  https://doi.org/10.1016/j.rasd.2006.10.002 CrossRefGoogle Scholar
  9. 9.
    Lane AE, Young RL, Baker AE, Angley MT (2010) Sensory processing subtypes in autism: association with adaptive behavior. J Autism Dev Disord 40(1):112–122.  https://doi.org/10.1007/s10803-009-0840-2 CrossRefPubMedGoogle Scholar
  10. 10.
    Dudova I, Hrdlicka M (2013) Olfactory functions are not associated with autism severity in autism spectrum disorders. Neuropsychiatr Dis Treat 9:1847–1851.  https://doi.org/10.2147/NDT.S54893 CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Brewer WJ, Brereton A, Tonge BJ (2008) Dissociation of age and ability on a visual analogue of the University of Pennsylvania Smell Identification Test in children with autism. Res Autism Spectr Disord 2(4):612–620.  https://doi.org/10.1016/j.rasd.2008.01.003 CrossRefGoogle Scholar
  12. 12.
    May T, Brewer WJ, Rinehart NJ, Enticott PG, Brereton AV, Tonge BJ (2011) Differential olfactory identification in children with autism and Asperger's disorder: a comparative and longitudinal study. J Autism Dev Disord 41(7):837–847.  https://doi.org/10.1007/s10803-010-1101-0 CrossRefPubMedGoogle Scholar
  13. 13.
    Kumazaki H, Muramatsu T, Kosaka H, Fujisawa TX, Iwata K, Tomoda A et al (2015) Sex differences in cognitive and symptom profiles in children with high functioning autism spectrum disorders. Res Autism Spectr Disord 13–14:1–7.  https://doi.org/10.1016/j.rasd.2014.12.011 CrossRefGoogle Scholar
  14. 14.
    Dunn W (1999) The sensory profile: examiner’s manual. The Psychological Corporation, San AntonioGoogle Scholar
  15. 15.
    McIntosh DN, Miller LJ, Shyu V, Dunn W (1999) Overview of the short sensory profile (SSP). In: Dunn W (ed) The sensory profile: examiner’s manual. The Psychological Corporation, San Antonio, pp 59–73Google Scholar
  16. 16.
    Schopler E, Reichler RJ, DeVellis RF, Daly K (1980) Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). J Autism Dev Disord 10(1):91–103CrossRefPubMedGoogle Scholar
  17. 17.
    Leekam SR, Libby SJ, Wing L, Gould J, Taylor C (2002) The Diagnostic Interview for Social and Communication Disorders: algorithms for ICD-10 childhood autism and Wing and Gould autistic spectrum disorder. J Child Psychol Psychiatry 43(3):327–342CrossRefPubMedGoogle Scholar
  18. 18.
    Wing L, Leekam SR, Libby SJ, Gould J, Larcombe M (2002) The diagnostic interview for social and communication disorders: background, inter-rater reliability and clinical use. J Child Psychol Psychiatry 43(3):307–325CrossRefPubMedGoogle Scholar
  19. 19.
    Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G (1997) ‘Sniffin’ sticks’: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses 22(1):39–52CrossRefPubMedGoogle Scholar
  20. 20.
    Davidson TM, Freed C, Healy MP, Murphy C (1998) Rapid clinical evaluation of anosmia in children: the Alcohol Sniff Test. Ann N Y Acad Sci 855:787–792CrossRefPubMedGoogle Scholar
  21. 21.
    Kobal G, Hummel T, Sekinger B, Barz S, Roscher S, Wolf S (1996) “Sniffin’ sticks”: screening of olfactory performance. Rhinology 34(4):222–226PubMedGoogle Scholar
  22. 22.
    Kobal G, Klimek L, Wolfensberger M, Gudziol H, Temmel A, Owen CM et al (2000) Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds. Eur Arch Otorhinolaryngol 257(4):205–211CrossRefPubMedGoogle Scholar
  23. 23.
    Doty RL, Shaman P, Dann M (1984) Development of the university of pennsylvania smell identification test: a standardized microencapsulated test of olfactory function. Physiol Behav 32(3):489–502CrossRefPubMedGoogle Scholar
  24. 24.
    Wiggins LD, Robins DL, Bakeman R, Adamson LB (2009) Brief report: sensory abnormalities as distinguishing symptoms of autism spectrum disorders in young children. J Autism Dev Disord 39(7):1087–1091.  https://doi.org/10.1007/s10803-009-0711-x CrossRefPubMedGoogle Scholar
  25. 25.
    Rogers SJ, Hepburn S, Wehner E (2003) Parent reports of sensory symptoms in toddlers with autism and those with other developmental disorders. J Autism Dev Disord 33(6):631–642CrossRefPubMedGoogle Scholar
  26. 26.
    Kientz MA, Dunn W (1997) A comparison of the performance of children with and without autism on the sensory profile. Am J Occup Ther 51(7):530–537CrossRefPubMedGoogle Scholar
  27. 27.
    Ben-Sasson A, Cermak SA, Orsmond GI, Tager-Flusberg H, Carter AS, Kadlec MB et al (2007) Extreme sensory modulation behaviors in toddlers with autism spectrum disorders. Am J Occup Ther 61(5):584–592CrossRefPubMedGoogle Scholar
  28. 28.
    Ashwin C, Chapman E, Howells J, Rhydderch D, Walker I, Baron-Cohen S (2014) Enhanced olfactory sensitivity in autism spectrum conditions. Mol Autism 5:53.  https://doi.org/10.1186/2040-2392-5-53 CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Dudova I, Vodicka J, Havlovicova M, Sedlacek Z, Urbanek T, Hrdlicka M (2011) Odor detection threshold, but not odor identification, is impaired in children with autism. Eur Child Adolesc Psychiatry 20(7):333–340.  https://doi.org/10.1007/s00787-011-0177-1 CrossRefPubMedGoogle Scholar
  30. 30.
    Suzuki Y, Critchley HD, Rowe A, Howlin P, Murphy DG (2003) Impaired olfactory identification in Asperger's syndrome. J Neuropsychiatry Clin Neurosci 15(1):105–107.  https://doi.org/10.1176/jnp.15.1.105 CrossRefPubMedGoogle Scholar
  31. 31.
    Tavassoli T, Baron-Cohen S (2012) Olfactory detection thresholds and adaptation in adults with autism spectrum condition. J Autism Dev Disord 42(6):905–909.  https://doi.org/10.1007/s10803-011-1321-y CrossRefPubMedGoogle Scholar
  32. 32.
    Kumazaki H, Muramatsu T, Fujisawa TX, Miyao M, Matsuura E, Okada K et al (2016) Assessment of olfactory detection thresholds in children with autism spectrum disorders using a pulse ejection system. Mol Autism 7:6.  https://doi.org/10.1186/s13229-016-0071-2 CrossRefPubMedPubMedCentralGoogle Scholar
  33. 33.
    Addo RN, Wiens S, Nord M, Larsson M (2017) Olfactory functions in adults with autism spectrum disorders. Perception 46(3–4):530–537.  https://doi.org/10.1177/0301006616686100 CrossRefPubMedGoogle Scholar
  34. 34.
    Zernecke R, Vollmer B, Albrecht J, Kleemann AM, Haegler K, Linn J et al (2010) Comparison of two different odorants in an olfactory detection threshold test of the Sniffin’™ Sticks. Rhinology 48(3):368–373.  https://doi.org/10.4193/Rhin09.212 CrossRefPubMedGoogle Scholar
  35. 35.
    Logan Darren W (2014) Do you smell what I smell? Genetic variation in olfactory perception. Biochem Soc Trans 42(4):861–865.  https://doi.org/10.1042/bst20140052 CrossRefPubMedGoogle Scholar
  36. 36.
    Doty RL, Marcus A, Lee WW (1996) Development of the 12-item cross-cultural smell identification test (CC-SIT). Laryngoscope 106(3 Pt 1):353–356CrossRefPubMedGoogle Scholar
  37. 37.
    Goudsmit N, Coleman E, Seckinger RA, Wolitzky R, Stanford AD, Corcoran C et al (2003) A brief smell identification test discriminates between deficit and non-deficit schizophrenia. Psychiatry Res 120(2):155–164CrossRefPubMedGoogle Scholar
  38. 38.
    Fukasawa A, Suzuki R, Okada K-I (2013) Olfactory measurement system to quantify the ability to smell using pulse ejection. Paper presented at the 2013 IEEE International Conference on Healthcare Informatics, Philadelphia, 9–11 September 2013. doi:  https://doi.org/10.1109/ichi.2013.19
  39. 39.
    Dalton P, Wysocki CJ (1996) The nature and duration of adaptation following long-term odor exposure. Percept Psychophys 58(5):781–792CrossRefPubMedGoogle Scholar
  40. 40.
    Matsuura E, Suzuki R, Homma S, Okada K (2015) Measurement of olfaction in children with autism by olfactory display using pulse ejection. International Journal of Informatics Society 7(3):123–130Google Scholar
  41. 41.
    Ohtsu K, Sato J, Bannai Y, Okada K-i (2009) Scent Presentation Technique of Pulse Ejection Synchronized with Breathing. Paper presented at the Ninth Annual International Symposium on Applications and the Internet SAINT 2009, Washington, 20–24 July 2009. doi:  https://doi.org/10.1109/saint.2009.28
  42. 42.
    Rozenkrantz L, Zachor D, Heller I, Plotkin A, Weissbrod A, Snitz K et al (2015) A mechanistic link between olfaction and autism spectrum disorder. Curr Biol 25(14):1904–1910CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Hirokazu Kumazaki
    • 1
    • 2
    Email author
  • Masako Okamoto
    • 3
    • 4
  • Sho Kanzaki
    • 5
  • Ken-ichi Okada
    • 6
  • Masaru Mimura
    • 2
  • Yoshio Minabe
    • 1
  • Mitsuru Kikuchi
    • 1
  1. 1.Research Center for Child Mental DevelopmentKanazawa UniversityKanazawaJapan
  2. 2.Department of NeuropsychiatryKeio University School of MedicineTokyoJapan
  3. 3.Department of Applied Biological Chemistry, Graduate School of Agricultural and Life SciencesThe University of TokyoTokyoJapan
  4. 4.ERATO Touhara Chemosensory Signal Project, JSTThe University of TokyoTokyoJapan
  5. 5.Department of Otorhinolaryngology, Head and Neck SurgeryKeio University School of MedicineTokyoJapan
  6. 6.Graduate School of Science and TechnologyKeio UniversityYokohamaJapan

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