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Large Porcine Model of Profound Acute Ischemic Cardiogenic Shock

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Experimental Models of Cardiovascular Diseases

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1816))

Abstract

Cardiogenic shock is one of the leading causes of death following acute myocardial infarction affecting 10% of patients with large myocardial infarcts with a subsequent mortality rate of 50%. Here we describe a large porcine model of acute ischemic cardiogenic shock. Acute left or right ventricular failure can be achieved with close to a 100% success rate by stepwise injection of microspheres into the left or right coronary artery, respectively, and the method allows for titration of heart failure to a prespecified level.

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Acknowledgments

We thank Dr. Janus A Hyldebrandt, Dr. Ann Banke, Dr. Charlotte Svejstrup Rud, Dr. Nanna Louise Junker Udesen, Dr. Henrik Schmidt, and Professor Lisette Okkels Jensen for their significant contributions to the experimental studies, enabling us to prepare this chapter.

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Authors and Affiliations

  1. Research Unit of Cardiology, Department of Cardiology, Odense University Hospital, Odense, Denmark

    Ole K. Møller-Helgestad MD & Professor Jacob E. Møller MD, PhD, DMSc

  2. Department of Cardiothoracic Anesthesia, The Heart Center, Rigshospitalet, Copenhagen, Denmark

    Professor Hanne B. Ravn MD, PhD, DMSc

Authors
  1. Ole K. Møller-Helgestad MD
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  2. Professor Hanne B. Ravn MD, PhD, DMSc
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  3. Professor Jacob E. Møller MD, PhD, DMSc
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Corresponding author

Correspondence to Ole K. Møller-Helgestad MD .

Editor information

Editors and Affiliations

  1. Icahn School of Medicine at Mount Sinai, New York, New York, USA

    Kiyotake Ishikawa

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Møller-Helgestad, O.K., Ravn, H.B., Møller, J.E. (2018). Large Porcine Model of Profound Acute Ischemic Cardiogenic Shock. In: Ishikawa, K. (eds) Experimental Models of Cardiovascular Diseases. Methods in Molecular Biology, vol 1816. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8597-5_27

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  • DOI: https://doi.org/10.1007/978-1-4939-8597-5_27

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8596-8

  • Online ISBN: 978-1-4939-8597-5

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