Advertisement

Analysis of Drugs of Abuse by Gas Chromatography–Mass Spectrometry (GC-MS)

  • Thomas A. Brettell
  • Benny J. Lum
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1810)

Abstract

Analysis of drugs of abuse constitutes a major portion of work for many crime laboratories. The most important and most utilized technique for the screening and identification of solid-dosage drugs is gas chromatography–mass spectrometry (GC-MS). A detailed practical procedure is described for the rapid screening and identification by GC-MS of most drugs of abuse that are commonly encountered in forensic drug laboratories.

Key words

Drug analysis Controlled substances Drugs of abuse Seized drugs GC-MS 

References

  1. 1.
    Audier H, Fetizon M, Ginsburg D, Mandelbaum A, Rull T (1965) Mass spectrometry of the morphine alkaloids. Tetrahedron Lett 6:13–22CrossRefGoogle Scholar
  2. 2.
    Bellman SW (1968) Mass spectral identification of some hallucinogenic drugs. J AOAC Int 51:164–178Google Scholar
  3. 3.
    Nigam IC, Holmes JL (1969) Mass spectrometry of lysergic acid diethylamide. J Pharm Sci 58:506–507CrossRefPubMedGoogle Scholar
  4. 4.
    Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG) http://www.swgdrug.org/approved.htm. Last accessed 22 May 2017
  5. 5.
    ASTM E-2329 Practice for the identification of seized drugs. ASTM International, West Conshohocken, PA E-2729-17 (2017)Google Scholar
  6. 6.
    McLafferty FW, Stauffer DA, Loh SY, Wesdemiotis C (1999) Unknown identification using reference mass spectra. Quality evaluation of databases. J Am Soc Mass Spectrom 10:1229–1240CrossRefPubMedGoogle Scholar
  7. 7.
    Adair AR, Noggle FT, Odom MS, Rhodes MA (1983) The ANOR (alternate non-aqueous organic ratio) extraction procedure. Micrograms XVI 1:220–228Google Scholar
  8. 8.
    Saloom JM (1983) Use of the ANOR method for separation of propoxyphene from propoxyphene + APC. Micrograms XVI 1:229–231Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Forensic Science Program, Department of Chemical & Physical SciencesCedar Crest CollegeAllentownUSA
  2. 2.Broward Sheriff’s Office Crime LaboratoryFort LauderdaleUSA

Personalised recommendations