Translingual Neurostimulation (TLNS): Perspective on a Novel Approach to Neurorehabilitation after Brain Injury

  • Yuri Danilov
  • Dafna Paltin
Part of the Neuromethods book series (NM, volume 139)


CN-NINM technology represents a synthesis of a new noninvasive brain stimulation technique with applications in physical medicine, cognitive, and affective neurosciences. Our new stimulation method appears promising for the treatment of a full spectrum of movement disorders and for both attention and memory dysfunction associated with traumatic brain injury. The integrated CN-NINM therapy proposed here aims to restore function beyond traditionally expected limits by employing both newly developed therapeutic mechanisms for progressive physical and cognitive training while simultaneously applying brain stimulation through a portable neurostimulation device called the PoNS™. Based on our previous research and recent pilot data, we believe a rigorous in-clinic CN-NINM training program, followed by regular at-home exercises that will also be performed with CN-NINM, will simultaneously enhance, accelerate, and extend recovery from multiple impairments (e.g. movement, vision, speech, memory, attention, and mood), based on divergent but deeply interconnected neurophysiological mechanisms of neuroplasticity.

Key words

Neurorehabilitation Neuromodulation Translingual neurostimulation PoNS device Targeted therapy Cranial nerve Neuroplasticity 



Cranial-nerve noninvasive neurostimulation


Multiple sclerosis


Traumatic brain injury


Translingual neurostimulation


Trigeminal nerve stimulation


Vagal nerve stimulation



This research is made possible by the additional efforts of Mitchell Tyler, Kim Skinner, Kurt Kaczmareck, Jannet Ruhland, and Georgia Corner.


The lead author has a financial interest in Advanced NeuroRehabilitation LLC and in Helius Medical Technologies, which both have intellectual property rights in the field of use reported in this article.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Yuri Danilov
    • 1
  • Dafna Paltin
    • 1
  1. 1.Department of KinesiologyUniversity of WisconsinMadisonUSA

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