Biogelx: Cell Culture on Self-Assembling Peptide Gels
Aromatic peptide amphiphiles can form self-supporting nanostructured hydrogels with tunable mechanical properties and chemical compositions. These hydrogels are increasingly applied in two-dimensional (2D) and three-dimensional (3D) cell culture, where there is a rapidly growing need to store, grow, proliferate, and manipulate naturally derived cells within a hydrated, 3D matrix. Biogelx Limited is a biomaterials company, created to commercialize these bio-inspired hydrogels to cell biologists for a range of cell culture applications. This chapter describes methods of various characterization and cell culture techniques specifically optimized for compatibility with Biogelx products.
Key wordsHydrogels Self-assembly Cell culture Biomaterials
- 16.Babu SS, Praveen VK, Ajayaghosh A (2014) Functional π-gelators and their applications. Chem Rev 144(4):1923–2129Google Scholar
- 17.Alakpa EV, Jayawarna V, Lampel A, Burgess KV, West CC, Bakker SCJ, Roy S, Javid N, Fleming S, Lamprou DA, Yang J, Miller A, Urquhart AJ, Frederix PWJM, Hunt NT, Péault B, Ulijn RV, Dalby MJ (2016) Tunable supramolecular hydrogels for selection of lineage-guiding metabolites in stem cell cultures. Chem 1:1–22CrossRefGoogle Scholar