Adipose-Derived Stromal Vascular Fraction Cells and Platelet-Rich Plasma: Basic and Clinical Implications for Tissue Engineering Therapies in Regenerative Surgery

  • Pietro Gentile
  • Valerio Cervelli
Part of the Methods in Molecular Biology book series (MIMB, volume 1773)


Cell-based therapy and regenerative medicine offer a paradigm shift in regard to various diseases causing loss of substance or volume and tissue or organ damage. Recently, many authors have focused their attention on mesenchymal stem cells for their capacity to differentiate into many cell lineages. The most widely studied types are bone marrow mesenchymal stem cells and adipose derived stem cells (ADSCs), which display similar results. Based on the literature, we believe that the ADSCs offer advantages because of lower morbidity during the harvesting procedure. Additionally, platelet-rich plasma can be used in this field for its ability to stimulate tissue regeneration. The aim of this chapter is to describe ADSC preparation and isolation procedures, preparation of platelet-rich plasma, and the application of ADSCs in regenerative plastic surgery. We also discuss the mechanisms and future role of ADSCs in cell-based therapy and tissue engineering.

Key words

Adipose stromal vascular cells Platelet-rich plasma Platelet rich lipotransfert Adipose-derived stem cells 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Pietro Gentile
    • 1
    • 2
  • Valerio Cervelli
    • 1
  1. 1.Department of Plastic and Reconstructive SurgeryUniversity of Rome “Tor Vergata”RomeItaly
  2. 2.Catholic UniversityTiraneAlbania

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