Using WormBase: A Genome Biology Resource for Caenorhabditis elegans and Related Nematodes

  • Christian GroveEmail author
  • Scott Cain
  • Wen J. Chen
  • Paul Davis
  • Todd Harris
  • Kevin L. Howe
  • Ranjana Kishore
  • Raymond Lee
  • Michael Paulini
  • Daniela Raciti
  • Mary Ann Tuli
  • Kimberly Van Auken
  • Gary Williams
  • The WormBase Consortium
Part of the Methods in Molecular Biology book series (MIMB, volume 1757)


WormBase ( provides the nematode research community with a centralized database for information pertaining to nematode genes and genomes. As more nematode genome sequences are becoming available and as richer data sets are published, WormBase strives to maintain updated information, displays, and services to facilitate efficient access to and understanding of the knowledge generated by the published nematode genetics literature. This chapter aims to provide an explanation of how to use basic features of WormBase, new features, and some commonly used tools and data queries. Explanations of the curated data and step-by-step instructions of how to access the data via the WormBase website and available data mining tools are provided.

Key words

Data mining Nematodes Genomics Genetics Caenorhabditis elegans Model organism database Ontologies User guide 



WormBase is supported by grant #U41 HG002223 from the National Human Genome Research Institute at the US National Institutes of Health, the UK Medical Research Council and the UK Biotechnology and Biological Sciences Research Council. At the time of writing, the WormBase Consortium included Paul W. Sternberg, Paul Kersey, Matthew Berriman, Lincoln Stein, Tim Schedl, Todd Harris, Scott Cain, Sibyl Gao, Paulo Nuin, Adam Wright, Kevin Howe, Bruce Bolt, Paul Davis, Michael Paulini, Faye Rodgers, Matthew Russell, Myriam Shafie, Gary Williams, Juancarlos Chan, Wen J. Chen, Christian Grove, Ranjana Kishore, Raymond Lee, Hans-Michael Müller, Cecilia Nakamura, Daniela Raciti, Gary Schindelman, Mary Ann Tuli, Kimberly Van Auken, Daniel Wang, and Karen Yook.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Christian Grove
    • 1
    Email author
  • Scott Cain
    • 2
  • Wen J. Chen
    • 1
  • Paul Davis
    • 3
  • Todd Harris
    • 2
  • Kevin L. Howe
    • 3
  • Ranjana Kishore
    • 1
  • Raymond Lee
    • 1
  • Michael Paulini
    • 3
  • Daniela Raciti
    • 1
  • Mary Ann Tuli
    • 1
  • Kimberly Van Auken
    • 1
  • Gary Williams
    • 3
  • The WormBase Consortium
  1. 1.Division of Biology and Biological EngineeringCalifornia Institute of TechnologyPasadenaUSA
  2. 2.Informatics and Bio-computing PlatformOntario Institute for Cancer ResearchTorontoCanada
  3. 3.European Molecular Biology LaboratoryEuropean Bioinformatics InstituteCambridgeUK

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