Population-Based Approaches to Alzheimer’s Disease Prevention

  • Robert Perneczky
Part of the Methods in Molecular Biology book series (MIMB, volume 1750)


Progress in prevention and treatment of Alzheimer’s disease (AD) and dementia is hampered by the restricted understanding of the biological and environmental causes underlying pathophysiology. It is widely accepted that certain genetic factors are associated with AD and a number of lifestyle and other environmental characteristics have also been linked to dementia risk. However, interactions between genes and the environment are not yet well understood, and coordinated global action is required to utilize existing cohorts and other resources effectively and efficiently to identify new avenues for dementia prevention. This chapter provides a brief summary of current research on risk and protective factors and opportunities and challenges in relation to population-based approaches are discussed.

Key words

Alzheimer’s disease Dementia Drug development Population-based Cohort studies Lifestyle Environment Genetics 



The author would like to thank the following individuals for their valuable contribution to the chapter: Profs Lefkos Middleton (Imperial College London, UK); Miia Kivipelto and Laura Fratiglioni (Karolinska Institutet Stockholm, Sweden); M. Arfan Ikram (Erasmus University Medical Center Rotterdam, The Netherlands); and Pascale Barberger-Gateau and Cécilia Samieri (Inserm U1219 and Bordeaux University, France).


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© Springer Science+Business Media, LLC 2018

Authors and Affiliations

  1. 1.Department of Psychiatry and PsychotherapyLudwig-Maximilians-Universität MünchenMunichGermany
  2. 2.German Center for Neurodegenerative Diseases (DZNE) MunichMunichGermany
  3. 3.Neuroepidemiology and Ageing Research Unit, School of Public HealthThe Imperial College of Science, Technology and MedicineLondonUK
  4. 4.West London Mental Health NHS TrustLondonUK

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